Beclin 2/BECN2抗体

产品货号：

Z11531

中文名称：

Beclin 2/BECN2抗体

英文名称：

Anti-Beclin 2/BECN2 Antibody

产品规格：

0.1mg

发货周期：

1～3天

产品价格：

询价

抗体名称	Anti-Beclin 2/BECN2 Antibody
指标别名	BECN2,BECN1L1,Beclin-1-like protein 1,Beclin 1 autophagy related pseudogene 1,BECN1P1
克隆性	Polyclonal
检验物种	human
应用范围	ELISA,WB,IHC,IF
基因名称	BECN2
抗体来源	Rabbit
抗体类型	IgG
免疫原	Beclin 2 antibody was raised against a 16 amino acid peptide near the amino terminus of human Beclin 2.The immunogen is located within amino acids 30 - 80 of Beclin 2.
计算分子量	48kDa
成分	Beclin 2 antibody is supplied in PBS containing 0.02% sodium azide.
纯化方式	Beclin 2 antibody is affinity chromatography purified via peptide column.
浓度	1mg/mL
产品形态	溶液
保存条件	4℃可保存3个月，-20℃可保存1年。
背景资料	Autophagy,the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2).Beclin 2 is a mammalian specific homolog of the autophagy protein Beclin 1 (3).Like Beclin 1,Beclin 2 interacts with Bcl-2 and class III PI3K complex components.However,Beclin 2 functions in an additional lysosomal degradation pathway and is required for ligand-induced endolysosomal degradation of several G protein-coupled receptors (3).Beclin 2 is also required for agonist-induced lysosome-mediated degradation of EGFR in lung cancer cells,suggesting that it may also play a role in regulating other intracellular signaling pathways (4).
Uniprot ID	A8MW95
基因名全称	Beclin 1,autophagy related,pseudogene 1
蛋白名全称	Beclin 1,autophagy related,pseudogene 1
推荐稀释比	Beclin 2 antibody can be used for detection of Beclin 2 by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested.

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